2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W017464R
    NAPQI (Standard) 50700-49-7 98%
    NAPQI (Standard) is the analytical standard of NAPQI (HY-W017464). This product is intended for research and analytical applications. NAPQI is the toxic metabolite of Acetaminophen (HY-66005). NAPQI is also an inhibitor of enzymes in the vitamin K cycle. NAPQI is rapidly detoxified by glutathione (GSH), but in situations of GSH deficiency, excess NAPQI reacts with cysteine residues in proteins, causing cell death and toxicity in the liver.
    NAPQI (Standard)
  • HY-W017469R
    Mesitaldehyde (Standard) 487-68-3
    Mesitaldehyde is an endogenous metabolite.
    Mesitaldehyde (Standard)
  • HY-W017490R
    3-Methylindolin-2-one (Standard) 1504-06-9 98%
    3-Methylindolin-2-one is an endogenous metabolite.
    3-Methylindolin-2-one (Standard)
  • HY-W017522R
    Adipic acid (Standard) 124-04-9 99.29%
    Adipic acid (Standard) (Hexanedioic acid (Standard)) is the analytical standard of Adipic acid (HY-W017522). This product is intended for research and analytical applications. Adipic acid (Hexanedioic acid) is an orally active compound with anti-HSV-1 activity. Adipic acid has low toxicity and can be used as a food additive and a gelling agent. Adipic acid can also be used in the synthesis of lubricants, artificial resins, plastics, etc.
    Adipic acid (Standard)
  • HY-W017523R
    5-Methoxy-5-oxopentanoic acid (Standard) 1501-27-5 98%
    5-Methoxy-5-oxopentanoic acid is an endogenous metabolite.
    5-Methoxy-5-oxopentanoic acid (Standard)
  • HY-W017540R
    Cyclocreatine (Standard) 35404-50-3 98%
    Cyclocreatine, a creatine analogue, acts as a brain-penetrant and potent bioenergetic protective agent by providing high levels of ATP. Cyclocreatine can be phosphorylated and dephosphorylated by creatine kinases. Cyclocreatine suppresses creatine metabolism ameliorating the cognitive, autistic and epileptic phenotype in a mouse model of creatine transporter defciency. Cyclocreatine protects against ischemic injury and enhances cardiac recovery during early reperfusion in dogs and rats. Cyclocreatine decreases plaque-adjacent neuronal dystrophy in TREM2-deficient mice with amyloid-β pathology. Cyclocreatine is proming for research of ischemic heart disease, cardiovascular diseases, Alzheimer’s disease and other neurodegenerative diseases associated with microglial dysfunction, prostate cancer.
    Cyclocreatine (Standard)
  • HY-W018161R
    Hexadecanedioic acid (Standard) 505-54-4 98%
    Hexadecanedioic acid (Thapsic acid) (Standard) is the analytical standard of Hexadecanedioic acid (HY-W018161). This product is intended for research and analytical applications. Hexadecanedioic acid is an orally active metabolite produced by B. uniformis. Hexadecanedioic acid inhibits IRE1α-XBP1s-mediated flipogenesis and ferroptosis. Hexadecanedioic acid downregulates XBP1 and Hrd1 expression, activates the Nrf2/SLC7A11/GPX4 pathway. Hexadecanedioic acid can be used for the research of metabolic-associated fatty liver disease.
    Hexadecanedioic acid (Standard)
  • HY-W018501R
    Methyl p-tert-butylphenylacetate (Standard) 3549-23-3 98%
    Methyl p-tert-butylphenylacetate (Standard) is the analytical standard of Methyl p-tert-butylphenylacetate. This product is intended for research and analytical applications. Methyl p-tert-butylphenylacetate is an endogenous metabolite.
    Methyl p-tert-butylphenylacetate (Standard)
  • HY-W018758R
    1-Phenylpropane-1,2-dione (Standard) 579-07-7
    1-Phenylpropane-1,2-dione, isolated from young Ephedra sinica Stapf (Ephedraceae), is biosynthetic precursors of the ephedrine alkaloids.
    1-Phenylpropane-1,2-dione (Standard)
  • HY-W018800R
    4(3H)-Quinazolinone (Standard) 491-36-1 98%
    4(3H) -quinazolinone is a fused nitrogen heterocyclic compound whose derivatives have a wide range of antimicrobial and antitumor activities.
    4(3H)-Quinazolinone (Standard)
  • HY-W019151S
    Meconin-d3 29809-15-2 98%
    Meconin-d3 is the deuterium labeled Meconine (HY-W019151). Meconine is an endogenous metabolite of Noscapine (HY-13716). Meconine is the major metabolite in all three species, accounting for about 3, 8 and 2% of the dose in the first 24 h urines of rats, rabbits and humans, respectively. Meconine can be used as a marker to detect illicit opiate use.
    Meconin-d3
  • HY-W019358R
    2-Hydroxymethyl benzoic acid (Standard) 612-20-4
    2-Hydroxymethyl benzoic acid is an endogenous metabolite.
    2-Hydroxymethyl benzoic acid (Standard)
  • HY-W019704R
    N-Acetyl-DL-methionine (Standard) 1115-47-5 98%
    N-Acetyl-DL-methionine (Standard) is the analytical standard of N-Acetyl-DL-methionine. This product is intended for research and analytical applications. N-Acetyl-DL-methionine is an endogenous metabolite.
    N-Acetyl-DL-methionine (Standard)
  • HY-W020658S
    18:0 PI-d6 98%
    18:0 PI-d6 (DSPI(18:0/18:0)-d6) is the deuterated form of 18:0 PI. 18:0 PI is a membrane-bound signaling molecule that is associated with almost all aspects of cell physiology, including cell growth, metabolism, proliferation, and survival.
    18:0 PI-d6
  • HY-W021425R
    D-Mannosamine hydrochloride (Standard) 5505-63-5 98%
    D-Mannosamine (hydrochloride) (Standard) is the analytical standard of D-Mannosamine (hydrochloride) (HY-W021425). This product is intended for research and analytical applications. D-Mannosamine ((2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal) hydrochloride is a six-carbon amino sugar and an amino derivative of D-mannose. D-Mannosamine hydrochloride can block mannose receptors.
    D-Mannosamine hydrochloride (Standard)
  • HY-W027553R
    Ipidacrine (Standard) 62732-44-9 98%
    Ipidacrine (Standard) is the analytical reference standard of Ipidacrine. This product is used for research and analytical applications. Ipidacrine is orally active and blood-brain-barrier-penetrant AChE and BuChE inhibitors with IC50 values of 1 μM and 1.9 μM, respectively, which is also a partial agonist of M2-cholinergic receptors and a reversible cholinesterase inhibitor. Ipidacrine has a stimulating effect on neuromuscular transmission and excitation along the nerve fibres with a moderately anti-pain effect. Ipidacrine is an aminopyridines and is structurally similar to Tacrine (HY-111338). Ipidacrine is effective in various amnesia models, improves erectile function and inhibits K+ and Na+-channels in the neuronal membrane in diabetic rats. Ipidacrine is promising for research of Alzheimer’s disease, ischaemic stroke, idiopathic neuropathy of the facial nerve, diabetes mellitus-induced erectile dysfunction and other deficits in central or peripheral cholinergic deseases.
    Ipidacrine (Standard)
  • HY-W027555R
    Ethoxyacetic acid (Standard) 627-03-2 98%
    Ethoxyacetic acid is an endogenous metabolite.
    Ethoxyacetic acid (Standard)
  • HY-W028943S
    (E)-3-Methyl-2-hexenoic acid-d5 98%
    (E)-3-Methyl-2-hexenoic acid-d5 ((2E)-3-Methyl-2-hexenoic acid-d5) is a deuterium labeled (E)-3-Methyl-2-hexenoic acid. (E)-3-Methyl-2-hexenoic acid is an axillary odor-related compound.
    (E)-3-Methyl-2-hexenoic acid-d5
  • HY-W037619R
    Pteridine-2,4(1H,3H)-dione (Standard) 487-21-8 98%
    Pteridine-2,4(1H,3H)-dione is an endogenous metabolite.
    Pteridine-2,4(1H,3H)-dione (Standard)
  • HY-W040141R
    L-Arabinitol (Standard) 7643-75-6 99.95%
    L-Arabinitol (Standard) is the analytical standard of L-Arabinitol. This product is intended for research and analytical applications. L-Arabinitol is a potential biomarker for the comsuption of the food products such as sweet potato, deerberry, moth bean, and is also associated with Alzheimer's disease and ribose-5-phosphate isomerase deficiency.
    L-Arabinitol (Standard)
Cat. No. Product Name / Synonyms Application Reactivity